LonP1 chaperone-like activity is ATPase independent and is mediated by its N-domain
Mette Ahrensback Roesgaard, Philipp Carlos Armbruster, Timothy Sharpe, Niko Schenck, Jan Pieter Abrahams
This paper shows LonP1 inhibits fibrillar aggregate growth without ATPase activity, localizing chaperone function to its N-domain hexamer.
bioRxiv · May 18, 2026 · PreprintBiochemistry