Author

Timothy Sharpe

University of BaselORCID 0000-0002-4980-1330Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:protein structure· 3 Organism:human· 2 Research Focus:protein design· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander WagneriD· 1 shared Anna-Sophia KrebsiD· 1 shared Carsten E. SeyfertiD· 1 shared Christoph DehioiD· 1 shared Daan OverwijniD· 1 shared Emiliya PoghosyaniD· 1 shared Fan CaoiD· 1 shared Gabriella ColluiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

Alexander WagnerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

LonP1 chaperone-like activity is ATPase independent and is mediated by its N-domain

Mette Ahrensback Roesgaard, Philipp Carlos Armbruster, Timothy Sharpe, Niko Schenck, Jan Pieter Abrahams

This paper shows LonP1 inhibits fibrillar aggregate growth without ATPase activity, localizing chaperone function to its N-domain hexamer.

bioRxiv · May 18, 2026 · PreprintBiochemistry

Tag with Caution - How protein tagging influences the formation of condensates

Kerstin Dörner, Michelle Jennifer Gut, Daan Overwijn, Fan Cao, Matej Siketanc, Stephanie Heinrich, Nicole Beuret, Justin Meyer, Timothy Sharpe, Kresten Lindorff‐Larsen, Maria Hondele

This study examines how protein tags affect condensate formation in different contexts and identifies charge as a key factor influencing condensation behavior.

EMBO Reports · Nov 20, 2025Peer-reviewedMolecular Biology

Full-length structure of the host targeted bacterial effector Bep1 reveals a novel structural domain conserved in FIC effector proteins from Bartonella

Markus Huber, Alexander Wagner, Jens Reiners, Carsten E. Seyfert, Timothy Sharpe, Sander H. J. Smits, Tilman Schirmer, Christoph Dehio

The paper determines the crystal structure of Bep1, revealing a novel FIC-OB-BAS(BID) domain arrangement and its role in T4SS translocation.

bioRxiv · Mar 25, 2024 · PreprintMicrobiology

Chimeric single α-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology

Gabriella Collu, Tobias Bierig, Anna-Sophia Krebs, Sylvain Engilberge, N. V. S. Varma, Ramón Guixà-González, Timothy Sharpe, Xavier Deupí, Vincent Oliéric, Emiliya Poghosyan, Roger Benoit

The paper demonstrates that the ER/K motif (SAH) can rigidly connect protein domains, enabling the formation of ordered crystals and new applications in protein nanotechnology.

Structure · Sep 28, 2021Peer-reviewedMolecular Biology