Author

Daehoon Lee

Case Western Reserve UniversityORCID 0000-0002-7930-2938Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1

Frequent Co-Authors

Wen‐Cheng XiongiD· 2 shared Andrea BallabioiD· 1 shared Changsu Han· 1 shared Chris M. Danson· 1 shared Chulman JoiD· 1 shared Davide CacchiarelliiD· 1 shared Hao-Han Guo· 1 shared Hoon RyuiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Wen‐Cheng XiongORCID

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3 papers

Recent·Most cited

Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health

James L. Daly, Chris M. Danson, Philip A. Lewis, Lu Zhao, Sara Riccardo, Lucio Di Filippo, Davide Cacchiarelli, Daehoon Lee, Stephen Cross, Kate J. Heesom, Wen‐Cheng Xiong, Andrea Ballabio, James R. Edgar, Peter J. Cullen

The paper uses a multiomic approach to study Retromer's role in lysosomal health in human neuroglioma cells, revealing proteomic and transcriptomic changes linked to neurodegeneration.

Nature Communications · May 29, 2023Peer-reviewedNeuroscience

ATP6AP2-to-MMP14, a key pathway for osteoblast to osteocyte transition

Lei Xiong, Hao-Han Guo, Jin‐Xiu Pan, Xiao Ren, Daehoon Lee, Lin Mei, Wen‐Cheng Xiong

This study identifies ATP6AP2 and MMP14 as critical for osteoblast-to-osteocyte transition, showing their role in osteocyte maturation, morphology, and bone matrix remodeling.

bioRxiv · Apr 27, 2022 · PreprintDevelopmental Biology

Alteration of Vascular Endothelial Cadherin in Alzheimer’s Disease Patient and Mouse Model

Daehoon Lee, Sun‐Jung Cho, Hyun Joung Lim, JiWoong Seok, Chulman Jo, Sangmee Ahn Jo, Moon Ho Park, Changsu Han, Neil W. Kowall, Hoon Ryu, Rudolph E. Tanzi, Young Ho Koh

This study shows decreased VE-cadherin levels in AD patients and mouse models, linked to amyloid pathology and plasma sVEC as a potential biomarker for AD risk.

bioRxiv · Sep 28, 2018 · PreprintNeuroscience