Stephen Cross

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

This study shows that loss of lmx1ba in zebrafish causes premature osteoarthritis by disrupting skeletal homeostasis and joint maintenance in adult life.

The paper investigates how Lamin A/C influences chromatin structure during early mammalian lineage segregation, showing its role in maintaining trophectoderm identity.

This paper designs globular proteins that drive biomolecular condensation and demonstrates their use in forming dynamic condensates in cells.

This study investigates how the Staphylococcus aureus SauUSI restriction enzyme recognizes and cleaves methylated DNA through ATP-driven translocation and loop formation.

The paper designs genetically encoded polypeptides that form membraneless organelles in E. coli and use them to co-compartmentalise a functional enzyme pair.

ModularImageAnalysis (MIA) provides a code-free workflow environment in ImageJ for automated image analysis, integrating modules for processing, object detection, and data export.

The paper uses a multiomic approach to study Retromer's role in lysosomal health in human neuroglioma cells, revealing proteomic and transcriptomic changes linked to neurodegeneration.

ENDO-Pore maps DNA cleavage events using nanopore sequencing, with CSI identifying cleavage sites, and it was benchmarked with restriction endonucleases and CRISPR Cas12a.

This study shows that Wnt signaling mediates mechanical strain responses during zebrafish joint development, affecting cell proliferation and migration but not chondrocyte intercalation.

This paper develops a zebrafish model to study joint dysplasia by manipulating the mechanical environment, identifying cellular factors that predict recovery of joint shape and function.