The paper develops and validates a method to quantify dynamic protein binding pockets using the HBV capsid assembly modulator site as a model, demonstrating robust performance across conformational states.

bioRxiv · Aug 10, 2026 · PreprintBiophysics

Assembly-active and -inactive forms of HBV capsid protein provide distinctly different binding sites for capsid assembly modulators

Liam W. Scott, Carolina Pérez-Segura, Jodi A. Hadden‐Perilla, Adam Zlotnick

This study compares the binding of CAMs to two forms of HBV capsid protein, showing structural differences in CAM site adaptation between assembly-active and -inactive forms.

bioRxiv · May 14, 2026 · PreprintBiochemistry

Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: HTRA1/lncRNA BX842242.1 dominates, with no evidence for Complement Cascade involvement

Samaneh Farashi, Carla J. Abbott, Brendan R. E. Ansell, Zhichao Wu, Lebriz Altay, Ella Arnon, Louis Arnould, Yelena Bagdasarova, Konstantinos Balaskas, Fred Kuanfu Chen, Emily Y. Chew, Itay Chowers, Steven Clarke, Catherine A. Cukras, Cécile Delcourt, , Melanie Bahlo

Nature Communications · Dec 8, 2025Peer-reviewedGenetic & Genomic Medicine

Bridging the gap: a prospective trial comparing programmable targeted long-read sequencing and short-read genome sequencing for genetic diagnosis of cerebellar ataxia

Haloom Rafehi, Liam G. Fearnley, Justin L. Read, Penny Snell, Kayli C. Davies, Liam W. Scott, Greta Gillies, Genevieve C. Thompson, Tess A. Field, Aleena Eldo, Simon Bodek, Ernest Gerard Butler, Luke Chen, John Drago, Himanshu Goel, , Paul J. Lockhart

This study compares short-read and long-read sequencing for diagnosing cerebellar ataxia, finding both effective but with different strengths in repeat expansion detection.

medRxiv · Jul 8, 2024 · PreprintGenetic & Genomic Medicine