Fred Kuanfu Chen

This study differentiates human induced pluripotent stem cells into limbal epithelial stem cells using a defined serum-free medium, showing increased expression of LESC markers by day 10.

This study evaluates RNA-targeting CRISPR-Cas13 and engineered U1 systems to reduce mis-spliced ABCA4 variants in Stargardt disease, showing significant reductions in disease-causing splice variants.

This study shows that knocking out POLDIP2 in human RPE cells reduces mitochondrial superoxide levels, linking POLDIP2 to oxidative stress in AMD.