BiochemistryBiochemistryPeer-reviewed
Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature
Jacob I. Stuckey, Valérie Vivat, Bradley M. Dickson…·Robert J. Sims
The paper investigates the thermodynamic effects of the Y220C TP53 mutation on Zn2+-binding and shows that Rezatapopt restores Zn2+-affinity through two pathways.
DOI 10.1021/acs.biochem.6c00068