Author

Robert J. Sims

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Gregg Chenail· 2 shared Jacob I. StuckeyiD· 2 shared James E. AudiaiD· 2 shared Jonathan E. WilsoniD· 2 shared Yong Li· 2 shared Bradley M. DicksoniD· 1 shared Byron DeLaBarre· 1 shared Christopher M. BaileyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Gregg Chenail

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature

Jacob I. Stuckey, Valérie Vivat, Bradley M. Dickson, Jeremy W. Setser, Yong Li, Claudia M. Cremers, Jonathan E. Wilson, Daniele Peterle, John R. Engen, Thomas E. Wales, Rainer Wilcken, Erin B. Rohan, Gregg Chenail, James E. Audia, Robert J. Sims

The paper investigates the thermodynamic effects of the Y220C TP53 mutation on Zn2+-binding and shows that Rezatapopt restores Zn2+-affinity through two pathways.

Biochemistry · Sep 1, 2026Peer-reviewedBiochemistry

Discovery and characterization of FX-909, a covalent inverse agonist of PPARG rationally designed to impose a powerful repressive bias in PPARG for the treatment of PPARG/RXRA-activated muscle-invasive urothelial cancers

Jacob I. Stuckey, Jennifer A. Mertz, Jonathan E. Wilson, Kaylyn E. Williamson, Yong Li, Miljan Kuljanin, Byron DeLaBarre, Gregg Chenail, Phuong Anh Nguyen, Christopher M. Bailey, William W. Motley, James E. Audia, Robert J. Sims

bioRxiv · May 8, 2025 · PreprintCancer Biology