JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation
Manuel Tavares, Garima Khandelwal, Joanne Muter, Keijo M. Viiri, Manuel Beltran-Nebot, Jan Joris Brosens, Richard G. Jenner
This study shows that JAZF1-SUZ12 fusion protein disrupts PRC2 function, leading to altered histone modifications and gene expression during cell differentiation.
Cell Reports · May 1, 2022Peer-reviewedMolecular Biology