Jan Joris Brosens

The paper develops a deep learning tool to analyze endometrial histology and identifies morphological correlates of miscarriage risk.

DCAFA analyzes histological images to identify compositional shifts and feature associations in biomedical data using a regression-based framework.

GOTFlow infers directed population transitions from cross-sectional biomedical data using optimal transport, revealing biologically meaningful dynamics in endometrial remodelling, breast cancer risk, and prion disease.

The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

This study shows miR-185-5p regulates pathways linked to implantation failure by altering protein expression and CNP family gene activity in endometrial cells.

The paper shows that PGE2's spatial targeting to very early endosomes is crucial for coordinating cAMP signaling in decidualizing human endometrium.

The paper uses single cell ATAC-seq to study chromatin remodeling in human endometrium across the menstrual cycle, identifying dynamic chromatin regions and their role in implantation.

This study shows that JAZF1-SUZ12 fusion protein disrupts PRC2 function, leading to altered histone modifications and gene expression during cell differentiation.

Endometrial assembloids of gland organoids and stromal cells reproduce midluteal cell states by scRNA-seq. Senescent decidual cells, tuned with dasatinib, track with whether co-cultured human blastocysts expand or stall.

The paper analyzes the exometabolome of decidualizing human endometrial stromal and perivascular cells to identify differentially secreted metabolites and their metabolic pathways during decidualization.

The paper links a pro-senescent decidual response during the peri-implantation window to recurrent pregnancy loss, showing that immune surveillance failure leads to progesterone-resistant cells and increased miscarriage risk.