Richard G. Jenner

This study shows G4 RNA inhibits PRC2 by binding to disordered loops in EZH2, preventing nucleosome interaction and modulated by SAM and peptides.

The paper reanalyzes CLAP data to show PRC2 directly interacts with RNA in cells, correcting previous findings that missed this interaction due to a scaling step.

The paper identifies a post-transcriptional regulatory checkpoint, ZFP36/ZFP36L1, that controls CD4+ T cell cytotoxicity and response to immunotherapy.

This study shows that JAZF1-SUZ12 fusion protein disrupts PRC2 function, leading to altered histone modifications and gene expression during cell differentiation.