Jogender Singh

RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response

The paper identifies CMTR-1 inhibition as a danger signal that activates an ELT-2-dependent immune response in C. elegans, enhancing resistance to Pseudomonas aeruginosa.

Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans that is alleviated by sugar supplementation

This study shows that bacterial metabolism of tryptophan to indole causes toxicity in C. elegans, which is reduced by sugar supplementation.

Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/β-catenin signaling

This study identifies USP-14 as a deubiquitinase that suppresses immune activation in C. elegans caused by gut distension via the Wnt/β-catenin pathway.

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways

The paper identifies E. coli mutants that extend C. elegans lifespan via oxidative stress and iron homeostasis pathways.

An acyltransferase protects Caenorhabditis elegans from thiol reductive stress through an autoinhibitory hypoxia response pathway

The paper identifies RHY-1 as a protective factor against thiol reductive stress in C. elegans, showing it is regulated by HIF-1 and functions in an autoinhibitory feedback loop.

Thiol reductive stress activates the hypoxia response pathway

This study shows thiol stress activates the hypoxia response pathway in C. elegans and humans, revealing a link between reductive stress and hypoxia signaling.