Wenliang Lei

This paper develops a non-human primate model of Alzheimer's disease by overexpressing human tau in the hippocampus, showing AD-like pathological features.

This study shows that enhancing NeuroD1 expression can convert astrocytes into neurons in mice, but lineage-traced astrocytes require stronger conversion signals.

The paper challenges a previous study on in vivo glia-to-neuron conversion by showing that high AAV doses cause artifacts and recommends safer dosages for reliable results.