Liang Xu

Looplook: Integrating multiomics refinement and graph clustering for target assignment and functional inference of chromatin regulatory networks

Looplook integrates 3D chromatin topology with functional genomics to improve CRE-target gene assignment and functional inference in chromatin regulatory networks.

Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regeneration

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice

This study shows that HuR deficiency in male mice increases susceptibility to APAP-induced liver injury by impairing xenobiotic metabolism and mitochondrial function.

Efficient Dlx2-mediated astrocyte-to-neuron conversion and inhibition of neuroinflammation by NeuroD1

This study shows Dlx2 converts astrocytes to neurons in the striatum, but induces neuroinflammation in white matter, which is suppressed by NeuroD1.

Enhancing NeuroD1 Expression to Convert Lineage-Traced Astrocytes into Neurons

This study shows that enhancing NeuroD1 expression can convert astrocytes into neurons in mice, but lineage-traced astrocytes require stronger conversion signals.

Comment on Rapid and efficient in vivo astrocyte-to-neuron conversion with regional identity and connectivity?

The paper challenges a previous study on in vivo glia-to-neuron conversion by showing that high AAV doses cause artifacts and recommends safer dosages for reliable results.