Zongqin Xiang

This study shows Dlx2 converts astrocytes to neurons in the striatum, but induces neuroinflammation in white matter, which is suppressed by NeuroD1.

This study shows that enhancing NeuroD1 expression can convert astrocytes into neurons in mice, but lineage-traced astrocytes require stronger conversion signals.

The paper challenges a previous study on in vivo glia-to-neuron conversion by showing that high AAV doses cause artifacts and recommends safer dosages for reliable results.