BiochemistrybioRxivPreprint
Identifying a cooperative catalytic network for efficient esterase catalysis
Sharad Sarak, Hong Yang, Colin T. Pierce…·Romas J. Kazlauskas
The paper redesigns an ancestral enzyme's active site to enhance esterase activity through cooperative residue substitutions and structural changes.
DOI 10.64898/2026.05.29.728779