Author

Colin T. Pierce

University of MinnesotaORCID 0000-0001-9506-9753Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:experimental assay· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Ke ShiiD· 2 shared Panhavuth TaniD· 2 shared Robert L. EvansiD· 2 shared Romas J. KazlauskasiD· 2 shared Sharad SarakiD· 2 shared Alana H. NguyeniD· 1 shared Allison Cafferty· 1 shared Anne Dao· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Ke ShiORCID

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2 papers

Recent·Most cited

Identifying a cooperative catalytic network for efficient esterase catalysis

Sharad Sarak, Hong Yang, Colin T. Pierce, Panhavuth Tan, Allison Cafferty, Anne Dao, Dana Junaidi, Ke Shi, Robert L. Evans, Romas J. Kazlauskas

The paper redesigns an ancestral enzyme's active site to enhance esterase activity through cooperative residue substitutions and structural changes.

bioRxiv · May 31, 2026 · PreprintBiochemistry

Crystal structures of forty- and seventy-one-substitution variants of hydroxynitrile lyase from rubber tree

Colin T. Pierce, Panhavuth Tan, Lauren R. Greenberg, Meghan E. Walsh, Ke Shi, Alana H. Nguyen, Elyssa L. Meixner, Sharad Sarak, Hideki Aihara, Robert L. Evans, Romas J. Kazlauskas

The paper describes the creation and structural analysis of HbHNL variants with 40 and 71 mutations to resemble SABP2, showing increased structural similarity to SABP2 with more mutations.

bioRxiv · Mar 30, 2025 · PreprintBiochemistry