Ke Shi

The paper redesigns an ancestral enzyme's active site to enhance esterase activity through cooperative residue substitutions and structural changes.

This study presents crystal structures of VNARs targeting sTNF- with distinct epitopes, showing selective antagonism without inducing reverse signaling.

This study reports the crystal structure of SsdA, a bacterial ssDNA deaminase, revealing its unique substrate binding mechanism and sequence-independent activity.

This study enhances the oxygen affinity of the DosS protein by modifying its heme coordination sphere, achieving a 150-fold increase in O2 binding affinity.

The paper describes the creation and structural analysis of HbHNL variants with 40 and 71 mutations to resemble SABP2, showing increased structural similarity to SABP2 with more mutations.

The paper investigates the functional relationships among DUX family members, showing that DUXA acts as a competitive inhibitor of DUX4 and shares target gene overlap with it.