ImmunologyNature Cardiovascular ResearchPeer-reviewed
CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2+ macrophages and CD8 T-cells
Jesús Jiménez, Junedh Amrute, Pan Ma…·Kory J. Lavine
This study shows CD40 agonists promote myocardial inflammation by activating CCR2+ macrophages and CD8 T-cells, leading to heart failure.
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