Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis
Celine I Wittke, Dale M. Watt, Liam Butler, Anabel Martinez Lyons, Cassie J. Clarke, Clara Mullen, Nicola Clements, Amy Lawlor, Dimitris Athineos, Ashleigh Young, Douglas Strathdee, Colin Nixon, Leonard J. Nelson, Thomas Graham Bird, Karen H. Vousden, , Timothy J. Humpton
This study shows that p53 and cholesterol drive liver fibrosis and systemic fibrosis in MASH, with sex-specific effects in mice.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology