Colin Nixon

Spatial Transcriptomics Reveals Region-Specific Host Responses in Amoebic Gill Disease of Atlantic Salmon

This study uses spatial transcriptomics to map immune responses in Atlantic salmon gills infected with AGD, revealing region-specific transcriptional domains and immune organization.

Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

This study shows that p53 and cholesterol drive liver fibrosis and systemic fibrosis in MASH, with sex-specific effects in mice.

Preclinical efficacy and safety of Tegavivint in Wnt-activated hepatocellular carcinoma

This study evaluates Tegavivint's efficacy and safety in Wnt-activated HCC, showing potent anti-tumour activity and safety in preclinical models.

Glandular architecture and malignant behaviour in colorectal cancer is regulated by the sialomucin Podocalyxin.

This study identifies Podocalyxin as a regulator of glandular architecture in colorectal cancer, showing its role in promoting tumour growth and metastasis.

Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis

This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.

Phenotype-dependent subtyping exposes high MYC activity as a targetable dependency in LuAd

The paper identifies high MYC activity as a targetable feature in lung adenocarcinoma using phenotype-based subtyping and shows sensitivity to a dual inhibitor of MYC co-factors.

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

Spatial resolution of transcriptomic plasticity states underpinning lethal morphologies in lung adenocarcinoma

This study uses spatial transcriptomics to analyze gene expression in lung adenocarcinoma morphologies, revealing plasticity and gene expression trajectories linked to lethal growth patterns.

Uridine Phosphorylase-1 supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes of the lung

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

Biomechanical Compartmentalisation Influences Angiogenesis and Stem Cell Proliferation in the Regenerating Intestine via Vascular Piezo.

This study identifies biomechanical compartmentalization in the regenerating intestine and shows vascular Piezo1 influences angiogenesis and stem cell proliferation across species.

Targeting Runx1 protects against heart failure with preserved ejection fraction

This study shows that inhibiting Runx1 protects against heart failure with preserved ejection fraction in mice by improving diastolic function and reducing hypertrophy and pulmonary edema.

Characterising neutrophil subtypes in cancer using human and murine single-cell RNA sequencing datasets

The paper identifies two neutrophil subtypes in cancer using single-cell RNA sequencing, showing their conservation across species and tumor types, and links them to immunosuppressive pathways.