Author

Timothy J. Humpton

Glasgow Caledonian UniversityORCID 0000-0002-8030-9539Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Celine I. WittkeiD· 2 shared Dale M. WattiD· 2 shared Dimitris AthineosiD· 2 shared Karen BlythiD· 2 shared Karen H. VousdeniD· 2 shared Liam ButleriD· 2 shared Nicola ClementsiD· 2 shared Amy LawloriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Celine I. WittkeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

Celine I Wittke, Dale M. Watt, Liam Butler, Anabel Martinez Lyons, Cassie J. Clarke, Clara Mullen, Nicola Clements, Amy Lawlor, Dimitris Athineos, Ashleigh Young, Douglas Strathdee, Colin Nixon, Leonard J. Nelson, Thomas Graham Bird, Karen H. Vousden, , Timothy J. Humpton

This study shows that p53 and cholesterol drive liver fibrosis and systemic fibrosis in MASH, with sex-specific effects in mice.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology

LIMK Inhibition and Metformin Block Mitochondrial Transfer Overcoming Macrophage Driven Therapy Resistance in Acute Myeloid Leukaemia

Ebubechukwu Nwarunma, Katerina E. Miari, Αθανασία Παπαδοπούλου, Stefan Corradini, Glen Watt, Samantha Hurwitz, Tatiana Fourfouris, Ki Jun Lee, Xenia Bubnova, Rebecca Briggs, Carl S. Goodyear, Theodoros Simakou, Marcus Doohan, Lucy MacDonald, Mariola Kurowska‐Stolarska, , Mark Thomas Shaw Williams

This study identifies mitochondrial transfer from M2-like macrophages to AML cells as a mechanism of chemoresistance, showing that LIMK inhibition and metformin block this transfer and restore chemosensitivity.

bioRxiv · Feb 5, 2026 · PreprintCancer Biology

p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

Celine I. Wittke, Eric C. Cheung, Dimitris Athineos, Nicola Clements, Liam Butler, Mark Hughes, Vivienne Morrison, Dale M. Watt, Karen Blyth, Karen H. Vousden, Timothy J. Humpton

This study shows that p53 and TIGAR protect against MASH by controlling redox balance, preventing ROS accumulation, fibrosis, and inflammation.

JHEP Reports · Mar 20, 2025Peer-reviewedCancer Biology