Author

Cassie J. Clarke

Cancer Research UK Scotland InstituteORCID 0000-0003-2232-1609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Colin NixoniD· 3 shared Karen BlythiD· 3 shared Dale M. WattiD· 2 shared David NovoiD· 2 shared David P. SumptoniD· 2 shared Douglas StrathdeeiD· 2 shared Emmanuel DornieriD· 2 shared Iain R. MacphersoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Colin NixonORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 3, 2026

Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

Celine I Wittke, Dale M. Watt, Liam Butler…·Timothy J. Humpton

This study shows that p53 and cholesterol drive liver fibrosis and systemic fibrosis in MASH, with sex-specific effects in mice.

DOI 10.64898/2026.09.02.748892

mousebulk RNA-seq

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Cancer BiologyEMBO ReportsPeer-reviewedJul 23, 2025

Uridine Phosphorylase-1 supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes of the lung

Declan Whyte, Sophie L Fisher, Christopher G J McKenzie…·Cassie J. Clarke

15 citationstop 3%

mouseexperimental assay

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Cancer BiologyThe Journal of Cell BiologyPeer-reviewedMay 7, 2025

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

Michalis Gounis, America V. Campos, Engy Shokry…·Cassie J. Clarke

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

6 citations

mouseproteomics

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