Karen H. Vousden

This study identifies SLC25A32 as a critical mitochondrial folate transporter that becomes essential in serine/glycine-starved triple-negative breast cancer, making it a potential therapeutic target.

This study identifies NAD+ limitation and α-ketoglutarate depletion as mechanisms by which pancreatic cancer cells induce muscle atrophy through metabolic rewiring and redox imbalance.

This study shows that dietary serine and glycine restriction delays cancer-associated cachexia in mice by altering host metabolism and reducing inflammation, independent of tumor growth.

This study shows that p53 and cholesterol drive liver fibrosis and systemic fibrosis in MASH, with sex-specific effects in mice.

The paper shows that winner cells in cell competition induce L-Proline uptake in loser cells, repressing the integrated stress response and leading to their elimination.

This study shows that p53 and TIGAR protect against MASH by controlling redox balance, preventing ROS accumulation, fibrosis, and inflammation.