Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer
Stephen L. DeAngelo, Liang Zhao, Sofia Dziechciarz, Myungsun Shin, Sumeet A. Solanki, Andrii Balia, Marwa O. El-Derany, Cristina Castillo, Yao Qin, Nupur Kanti Das, Hannah Noelle Bell, João A. Paulo, Yuezhong Zhang, Nicholas J. Rossiter, Elizabeth C. McCulla, , Yatrik Madhukar Shah
This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.
Cancer Research · May 19, 2025Peer-reviewedCancer Biology