Engulfing to Adapt: Efferocytosis by Epithelial Cells Triggers Cell State Transitions During Tissue Remodeling
Adda-Lee Graham-Paquin, Deepak Saini, Sophie Viala, Mara KM Whitford, Mathieu R. Tremblay, William A. Pastor, Luke Martin McCaffrey
The paper shows that efferocytosis by epithelial cells during hormone deprivation in prostate cancer triggers metabolic and gene expression changes that reprogram cells for regeneration.
bioRxiv · Jul 31, 2025 · PreprintDevelopmental Biology