Author

Jacinthe Sirois

Institut du cancer Rosalind & Morris Goodman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Deepak SainiiD· 3 shared William A. PastoriD· 3 shared Ishtiaque HossainiD· 2 shared Sin Young Kwon· 2 shared Adda-Lee Graham-PaquiniD· 1 shared Anissa Mourali· 1 shared Anna-Maria PrandstetteriD· 1 shared Christopher MoraesiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMolecular Biology

Deepak SainiORCID

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Author profile →

4 papers

Recent·Most cited

Jag2 patterns early differentiation in the epidermal stem cell layer

Sophie Viala, Vandana Nathan, Jacinthe Sirois, Olivia Costanzo, Daniela Perez Laguna, Mauna Musulchi, Milan Heck, Anissa Mourali, Michael H. Mouradian, Katie Cockburn

The paper shows that stem cells in the epidermis use Jag2 to influence neighboring cell differentiation, maintaining tissue structure and function.

bioRxiv · Sep 11, 2026 · PreprintCell Biology

Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells

Jessica K. Cinkornpumin, Sin Young Kwon, Anna-Maria Prandstetter, Theresa Maxian, Jacinthe Sirois, James Goldberg, Joy Zhang, Deepak Saini, Purbasa Dasgupta, Mariyan J. Jeyarajah, Stephen James Renaud, Soumen Paul, Sandra Haider, William A. Pastor

Stem Cell Reports · Apr 24, 2025Peer-reviewedCell Biology

ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development

Adda-Lee Graham-Paquin, Deepak Saini, Jacinthe Sirois, Ishtiaque Hossain, Megan S. Katz, Qinwei Kim-Wee Zhuang, Sin Young Kwon, Yojiro Yamanaka, Guillaume Bourque, Maxime Bouchard, William A. Pastor

This study identifies ZMYM2 as essential for DNA methylation and silencing of germline genes and active transposons in embryonic development, revealing its role in maintaining genomic stability.

Nucleic Acids Research · Jun 10, 2023Peer-reviewedMolecular Biology

The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells

Nathália Azevedo Portilho, Deepak Saini, Ishtiaque Hossain, Jacinthe Sirois, Christopher Moraes, William A. Pastor

This study compares the demethylation efficacy and toxicity of GSK-3484862 and 5-azanucleosides in murine embryonic stem cells, finding GSK-3484862 induces more effective demethylation with less toxicity.

Epigenetics & Chromatin · Dec 1, 2021Peer-reviewedMolecular Biology