Author

Simone de Jong

King's College LondonORCID 0000-0002-8002-7195Unclaimed ORCID profile · follow to get notified of new preprints

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Organism:human· 5 Approach:statistical model· 5 Assay:GWAS summary statistics· 3 Research Focus:GWAS / association mapping· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Andreas J. ForstneriD· 3 shared Esben AgerboiD· 3 shared Franziska DegenhardtiD· 3 shared Gerome D. BreeniD· 3 shared Héléna A. GaspariD· 3 shared Jonas Bybjerg‐GrauholmiD· 3 shared Jonathan R. I. ColemaniD· 3 shared Josef FrankiD· 3 shared

Activity by Year

2017-2020 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Andreas J. ForstnerORCID

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5 papers

Recent·Most cited

Integrative genomic strategies applied to a lymphoblast cell line model reveal specific transcriptomic signatures associated with clozapine response

SAJ de With, Anil P. S. Ori, Tina Wang, Sara L. Pulit, Eric Strengman, Joana F. Viana, Jonathan S. Mill, Simone de Jong, Roel A. Ophoff

The paper investigates clozapine's molecular effects using lymphoblastoid cell lines, identifying transcriptomic and epigenomic changes linked to cholesterol and metabolic pathways.

bioRxiv · Sep 22, 2020 · PreprintGenomics

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer, Jose Guzman Parra, Fabian Streit, Jana Strohmaier, Maria José González, Susana Gil Flores, Francisco Cabaleiro, Francisco del Río Noriega, Fermín Pérez, Jesus Haro González, Guillermo Orozco Díaz, Yolanda de Diego‐Otero, Berta Moreno‐Küstner, Georg W. J. Auburger, Franziska Degenhardt, , Claudia Giambartolomei

The paper examines common genetic variants' contribution to bipolar disorder risk in multiplex families and finds higher polygenic risk scores in affected individuals compared to controls and unaffected family members.

Molecular Psychiatry · Nov 11, 2019Peer-reviewedGenetics

Genomewide association study identifies 30 loci associated with bipolar disorder

Eli A. Stahl, Gerome D. Breen, Andreas J. Forstner, Andrew McQuillin, Stephan Ripke, Vassily Trubetskoy, Manuel Mattheisen, Yunpeng Wang, Jonathan R. I. Coleman, Héléna A. Gaspar, Christiaan de Leeuw, Stacy Steinberg, Jennifer M. Whitehead Pavlides, Maciej Trzaskowski, Enda M. Byrne, , Anders Juréus

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.

Nature Genetics · May 1, 2019Peer-reviewedGenetics

Applying polygenic risk scoring for psychiatric disorders to a large family with Bipolar Disorder and Major Depressive Disorder

Simone de Jong, Mateus Jose Abdalla Diniz, Andiara Saloma, Ary Gadelha, Marcos Leite Santoro, Vanessa Ota, Cristiano de Souza Noto, Naomi R. Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M. Byrne, Abdel Abdellaoui, Mark J. Adams, Esben Agerbo, , Jodie N. Painter

The paper applies polygenic risk scoring to a large family with bipolar and depressive disorders to study genetic risk patterns and anticipation.

Communications Biology · Oct 2, 2018Peer-reviewedGenetics

Whole genome linkage analysis in a large Brazilian multigenerational family reveals distinct linkage signals for Bipolar Disorder and Depression.

Mateus Jose Abdalla Diniz, Andiara Saloma, Ary Gadelha, Shaza Alsabban, Camila Guindalini, Jose Luis Paya-Cano, Simone de Jong, Peter McGuffin, Rodrigo A. Bressan, Gerome D. Breen

The paper performs linkage analysis in a large Brazilian family to identify genetic regions associated with bipolar disorder and depression, finding four genome-wide significant and four suggestive linkage regions but no strong joint support across analyses.

bioRxiv · Feb 6, 2017 · PreprintGenetics