This study presents a high-coverage whole-genome sequencing dataset of 1,171 admixed elderly Brazilians, identifying novel variants and demonstrating the utility of WGS for genomic and clinical research in underrepresented populations.

Nature Communications · Mar 4, 2022Peer-reviewedGenomics

Immunogenetics of resistance to SARS-CoV-2 infection in discordant couples

Erick C. Castelli, Mateus Vidigal de Castro, Michel Satya Naslavsky, Marília O. Scliar, Nayane dos Santos Brito Silva, Heloisa S. Andrade, Andréia S. Souza, Raphaela Neto Pereira, Camila Ferreira Bannwart Castro, Celso Teixeira Mendes‐Junior, Diogo Meyer, Kelly Nunes, Larissa R. B. Matos, Moníze V. R. Silva, Jaqueline Yu Ting Wang, , Mayana Zatz

The paper identifies genetic variants associated with resistance to SARS-CoV-2 infection by analyzing discordant Brazilian couples.

Frontiers in Immunology · Sep 28, 2021Peer-reviewedGenetic & Genomic Medicine

KIR2DL4 genetic diversity in a Brazilian population sample: implications for transcription regulation and protein diversity in samples with different ancestry backgrounds

Emiliana Weiss, Heloisa S. Andrade, Juliana Rodrigues Lara, Andréia S. Souza, Michelle A. Paz, Thálitta H. A. Lima, Iane de Oliveira Pires Porto, Nayane dos Santos Brito Silva, Camila Ferreira Bannwart Castro, Rejane Maria Tommasini Grotto, Eduardo Antônio Donadi, Celso Teixeira Mendes‐Junior, Erick C. Castelli

The paper characterizes KIR2DL4 genetic diversity in a Brazilian population, identifies new sequences, and shows ancestry influences allele frequencies.

Immunogenetics · Feb 17, 2021Peer-reviewedGenetics