In vitro assessment of an engineered tBID-based safety switch system in human T lymphocytes
Jiamiao Lu, Patrick J. Collins, Ki Jeong Lee, Chi-Ming Li, Songli Wang
This study develops and tests a tBID-based safety switch system for engineered T cells to manage toxicity and persistence, showing up to 90% cell elimination in vitro.
Annals of Translational Medicine · Nov 1, 2021Peer-reviewedMolecular Biology