Pankaj Kumar

IRG1/itaconate/NRF2/GSH axis in tumor-associated macrophages drives therapy resistance and immune evasion in BRCA1-deficient breast cancer

This study identifies the IRG1/itaconate/NRF2/GSH axis in TAMs as a driver of PARPi resistance and immune evasion in BRCA1-deficient breast cancer, with pharmacological inhibition showing therapeutic potential.

Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

The paper identifies master regulatory miRNAs in glioblastoma and develops a therapeutic delivery method to inhibit tumor growth.

Short-term diet intervention alters the small non-coding RNA (sncRNA) landscape of human sperm

The paper shows diet intervention alters sncRNA expression in human sperm, linking paternal nutrition to offspring health through epigenetic changes.

tRForest: a novel random forest-based algorithm for tRNA-derived fragment target prediction

tRForest improves tRNA fragment target prediction using random forest, validated in cell lines and showing enrichment in neuronal function.

M-CAMP™: A cloud-based web platform with a novel approach for species-level classification of 16S rRNA microbiome sequences

M-CAMP provides a cloud-based platform with a novel 16S rRNA classification algorithm that achieves high accuracy in species-level microbiome analysis.

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancers and cell lines

The paper shows that ATAC-seq can detect thousands of extrachromosomal circular DNAs in cancer and cell lines without specific enrichment.

The Pan-Cancer Landscape of Prognostic Germline Variants in 10,582 Patients

The paper identifies prognostic germline variants in 10,582 cancer patients using multivariate Cox regression, showing their association with patient outcomes beyond clinical data.

Extrachromosomal circular DNA, microDNA, without canonical promoters produce short regulatory RNAs that suppress gene expression

The paper shows that microDNA produces regulatory RNAs that suppress gene expression through miRNA and si-like RNA mechanisms.

Global Gene Repression By Dicer-Independent tRNA Fragments

The paper identifies tRF-3 fragments that repress gene expression through Argonaute-dependent seed sequence matching, independent of Dicer.