Dnmt3a-mutant Leukemia Stem Cells evade chemotherapy through enforced quiescence in Npm1c-Flt3ITD Acute Myeloid Leukemia
Paniz Tavakoli Shirazi, Jasmin Straube, Victoria Ling, Stacey B. Andersen, Emily Cooper, Siu Hang Natalie Chan, Rohit Haldar, Yashaswini Janardhanan, Leanne T. Cooper, Claudia Bruedigam, Carolyn S. Grove, Megan J. Bywater, Steven Lane
This study shows that DNMT3A mutations in AML promote chemotherapy resistance by enforcing quiescence in leukemia stem cells, which can be reversed with pegIFN to restore sensitivity.
bioRxiv · Jun 8, 2026 · PreprintCancer Biology