Author

Audrey Leprince

Université LavalORCID 0000-0002-8068-1365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Anne M. Millen· 2 shared Damian MagilliD· 2 shared Dennis A. RomeroiD· 2 shared Geneviève M. RousseauiD· 2 shared Justine Lefrançois· 2 shared Philippe HorvathiD· 2 shared Sylvain MoineauiD· 2 shared Alexandre BoulayiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

Anne M. Millen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Uncovering novel phage defense systems through genomic island analysis in Streptococcus thermophilus

Audrey Leprince, Vincent Somerville, Justine Lefrançois, Geneviève M. Rousseau, Anne M. Millen, Damian Magill, Philippe Horvath, Dennis A. Romero, Sylvain Moineau

This study identifies novel antiviral defense systems in Streptococcus thermophilus by analyzing genomic islands, revealing previously uncharacterized systems and highlighting their role as reservoirs of bacterial immunity.

bioRxiv · Oct 5, 2026 · PreprintMicrobiology

Empathi: Embedding-based Phage Protein Annotation Tool by Hierarchical Assignment

Alexandre Boulay, Audrey Leprince, François Enault, Elsa Rousseau, Clovis Galiez

Empathi improves phage protein function annotation by using hierarchical embeddings, outperforming homology-based methods and increasing annotated protein families.

Nature Communications · Oct 14, 2025Peer-reviewedBioinformatics

Strengthening Phage Resistance of Streptococcus thermophilus by Leveraging Complementary Defense Systems

Audrey Leprince, Justine Lefrançois, Anne M. Millen, Damian Magill, Philippe Horvath, Dennis A. Romero, Geneviève M. Rousseau, Sylvain Moineau

This study identifies and validates 21 accessory defense systems in S. thermophilus, showing that some provide stronger phage resistance than CRISPR-Cas, especially when combined or expressed from plasmids.

Nature Communications · Aug 4, 2025Peer-reviewedMicrobiology