Suzanne C. Hoppins

MSTO1 functions as a TRiC assembly factor linking cytosolic proteostasis to mitochondrial function

This study identifies MSTO1 as a TRiC assembly factor, showing that its loss leads to reduced TRiC levels and mitochondrial dysfunction, linking cytosolic proteostasis to mitochondrial health.

Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1.

This study uses tmFRET to analyze GTP-coupled conformational changes in Mfn1, revealing an unexpected conformational reversal and heterogeneous transition-state ensemble.

Full-length isoform sequencing for resolving the molecular basis of Charcot-Marie-Tooth 2A

The paper uses full-length isoform sequencing to identify a splicing defect in MFN2 causing CMT2A in a patient with undiagnosed neuropathy.