Molecular BiologyNature CommunicationsPeer-reviewed
Interaction Between Transcribing RNA Polymerase and Topoisomerase I Prevents R-loop Formation in E. coli
Dmitry A. Sutormin, Alina Galivondzhyan, Olga S. Musharova…·Konstantin Severinov
The paper shows that TopoI interacts with RNA polymerase in E. coli to prevent R-loop formation by relaxing negative supercoiling during transcription.