Author

Sergei I. Borukhov

Rowan UniversityORCID 0000-0002-3517-3003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Assay:ChIP-seq· 1 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Konstantin SeverinoviD· 4 shared Maria L. SokolovaiD· 3 shared Arina V. Drobysheva· 2 shared Eugene V. KooniniD· 2 shared Kira S. MakarovaiD· 2 shared P.G. LeimaniD· 2 shared Минахин Леонид СтаниславовичiD· 2 shared Alec FraseriD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMolecular Biology

Konstantin SeverinovORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail

Anastasiia Chaban, Минахин Леонид Станиславович, Ekaterina Goldobina, Brain Bae, Yue Hao, Sergei I. Borukhov, Leena Putzeys, Maarten Boon, Florian Kabinger, Rob Lavigne, Kira S. Makarova, Eugene V. Koonin, Satish K. Nair, Shunsuke Tagami, Konstantin Severinov, Maria L. Sokolova

The paper identifies and characterizes two RNA polymerases in a thermophilic virus, showing their structural and functional differences and evolutionary origin.

Nature Communications · Jan 5, 2024Peer-reviewedMolecular Biology

Interaction Between Transcribing RNA Polymerase and Topoisomerase I Prevents R-loop Formation in E. coli

Dmitry A. Sutormin, Alina Galivondzhyan, Olga S. Musharova, Dmitrii Y. Travin, Anastasiia N. Rusanova, Kseniya Obraztsova, Sergei I. Borukhov, Konstantin Severinov

The paper shows that TopoI interacts with RNA polymerase in E. coli to prevent R-loop formation by relaxing negative supercoiling during transcription.

Nature Communications · Aug 4, 2022Peer-reviewedMolecular Biology

Template strand deoxyuridine promoter recognition by a viral RNA polymerase

Alec Fraser, Maria L. Sokolova, Arina V. Drobysheva, Julia Gordeeva, Sergei I. Borukhov, Tatyana Artamonova, AlphaFold Team, Konstantin Severinov, P.G. Leiman

This study elucidates how the AR9 bacteriophage's non-virion RNA polymerase recognizes uracil-containing promoters in the template strand of dsDNA through a unique structural mechanism.

Nature Communications · Jun 20, 2022Peer-reviewedMolecular Biology

Structure and function of virion RNA polymerase of crAss-like phage

Arina V. Drobysheva, Софья Андреевна Панафидина, Matvey V. Kolesnik, Evgeny I. Klimuk, Минахин Леонид Станиславович, Maria V. Yakunina, Sergei I. Borukhov, Emelie Nilsson, Karin Holmfeldt, Natalya Yutin, Kira S. Makarova, Eugene V. Koonin, Konstantin Severinov, P.G. Leiman, Maria L. Sokolova

The paper characterizes the structure and function of a novel DNA-dependent RNA polymerase from a crAss-like phage, showing its role in phage gene transcription and structural similarity to eukaryotic RNA interference polymerases.

Nature · Nov 18, 2020Peer-reviewedMolecular Biology