Ciaran P. Seath

The paper identifies SLK as a cancer-specific co-regulator of c-Myc using photoproximity labeling, showing it stabilizes c-Myc and drives tumorigenesis through splicing changes.

The paper identifies RNA binding by mutant p53 and shows it contributes to mitochondrial dysfunction through altered miRNA processing.

DeSciDe ranks gene lists using precedence and connectivity metrics to identify novel biological insights, revealing a new loss of function role for the H2A E92K mutation.

FlAsH-ID is a short peptide-based photoproximity labeling method that labels protein interactions in live cells without disrupting function, demonstrating its utility in studying small transcription factors in primary T cells.

This study shows RNase L reduces antiviral proteins by inhibiting mRNA export and RNAPII-mediated transcription during flavivirus infection.

The paper introduces MesoMap, a mesoscale proximity labeling method to study chromatin occupancy changes, showing how HDAC inhibitors and the drug SR-1815 affect gene expression.

This paper introduces a photocatalytic method for drug target identification that improves signal-to-noise and enables detection of low-abundance targets.