Mark A. Dawson

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper identifies SF3B3 and SF3B5 as a transcription module within the U2 snRNP that regulates Pol II elongation independently of splicing.

This study distinguishes tissue-resident memory (TRM) and exhausted T (TEX) cells in tumors by analyzing their antigen reactivity, clonality, and functional outcomes.

The paper shows that inhibiting KAT6/KAT7 enhances Menin inhibitor efficacy and overcomes resistance in MLL-FP leukemia.

The paper compares functional properties of fetal and adult hematopoietic stem/progenitor cells through transplantation, revealing differences in lineage bias and clonal multi-lineage differentiation.

The paper identifies cofactors required by different transcription factors and promoters using CRISPR-Cas9 screens and shows that unique cofactor combinations influence transcriptional steps.

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

BARtab and bartools provide a scalable pipeline and R package for analyzing synthetic cellular barcodes in genomic and transcriptomic data.

This study benchmarks seven HTO demultiplexing tools using datasets with genetic variant-based ground truth, finding similar performance on high-quality data but poor performance on lower quality data for bimodal distribution methods.

The paper introduces CRISPR-ChIP to identify chromatin factors associated with histone modifications in MLL-leukaemia, revealing distinct DOT1L complexes with oncogenic and endogenous functions.

The paper identifies endogenous retroviruses (ERVs) as a source of oncogenic enhancers in acute myeloid leukemia (AML) and shows their role in altering gene expression and promoting cell growth.

This study shows that 5-formylcytosine (5fC) influences nucleosome positioning through covalent histone-DNA interactions in mouse embryonic stem cells.