Author

Xun Sun

Scripps Research InstituteORCID 0000-0002-8079-5530Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xun Sun1 paper · Paul Scherrer Institute

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

H. Jane DysoniD· 2 shared James A. FergusoniD· 2 shared Peter E. WrightiD· 2 shared Benjamin I. LeachiD· 1 shared David OyeniD· 1 shared Gareth J. MorganiD· 1 shared Gerard J. A. KrooniD· 1 shared Ke YangiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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2 shared papersBiophysics

H. Jane DysonORCID

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2 papers

Recent·Most cited

Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer

Xun Sun, James A. Ferguson, Ke Yang, Robyn L. Stanfield, H. Jane Dyson, Peter E. Wright

This paper investigates how mispacking of the F87 sidechain in transthyretin tetramers affects conformational dynamics and aggregation propensity through structural and biophysical analyses.

Protein Science · Aug 16, 2024Peer-reviewedBiophysics

Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion

Benjamin I. Leach, James A. Ferguson, Gareth J. Morgan, Xun Sun, Gerard J. A. Kroon, David Oyen, H. Jane Dyson, Peter E. Wright

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.

Journal of Molecular Biology · Jan 1, 2024Peer-reviewedBiophysics