Author

Benjamin I. Leach

Scripps Research InstituteORCID 0000-0002-7379-314XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam M. BoultoniD· 1 shared Akihiko YokoyamaiD· 1 shared Alyna KattiiD· 1 shared Ashish KabraiD· 1 shared Brandon F Malone· 1 shared David J. HugginsiD· 1 shared David OyeniD· 1 shared Dimitrios G. AnastasakisiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

Adam M. BoultonORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 1, 2025

The MLLT3 YEATS domain is a dual reader of histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking epigenetic and RNA signaling to regulate hematopoiesis

Adam M. Boulton, Ashish Kabra, Nicholas J. Achille…·John Hackett Bushweller

This study shows the MLLT3 YEATS domain binds both histone marks and the 7SK RNA, influencing hematopoietic lineage commitment and gene expression.

DOI 10.1101/2025.09.01.673558

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 4, 2025

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression

Jill Zimmerman, Brandon F Malone, Efrat Finkin-Groner…·Lukas E. Dow

The paper identifies a TNKS2-selective inhibitor that enables tumor-selective WNT suppression by exploiting 8p loss in cancer cells.

DOI 10.1101/2025.03.04.641305

humanexperimental assay

𝕏 PostBluesky

BiophysicsJournal of Molecular BiologyPeer-reviewedJan 1, 2024

Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion

Benjamin I. Leach, James A. Ferguson, Gareth J. Morgan…·Peter E. Wright

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.

13 citationstop 4%

protein structurebiophysical modeling

𝕏 PostBluesky