Gareth J. Morgan

Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway

The paper reports cryo-EM structures of cardiac AL amyloid fibrils from IGLV6 light chains, revealing conserved structural motifs and sequence-dependent folding mechanisms.

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry

This study identifies small molecules that stabilize diverse amyloidogenic immunoglobulin light chains by reducing conformational dynamics and proteolysis.

An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis

The paper updates the AL-Base database and identifies enriched immunoglobulin light chain variable genes in AL amyloidosis, showing some genes are highly enriched and others have mutation patterns distinct from other conditions.