Author

Thomas Hollin

Department of Molecular, Cell and Systems Biology, University of California, RiversideORCID 0000-0002-8089-3253Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:Hi-C· 1

Frequent Co-Authors

Anita SarafiD· 2 shared Jacques G. PrudhommeiD· 2 shared Karine G. Le RochiD· 2 shared Laurence A. FlorensiD· 2 shared Zeinab M ChahineiD· 2 shared A. Garcia-Perez· 1 shared Amy Kristine BeiiD· 1 shared Anasuya Chattopadhyay PaliD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMicrobiology

Anita SarafORCID

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2 papers

Recent·Most cited

MicrobiologySciencePeer-reviewedSep 26, 2024

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Zeinab M Chahine, S. Abel, Thomas Hollin…·Karine G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

18 citationstop 3%

humanexperimental assay

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MicrobiologybioRxivSep 11, 2023

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

Zeinab M Chahine, Mohit Gupta, Todd Lenz…·Karine G Le Roch

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

DOI 10.7554/elife.92499

humanChIP-seq

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