Jay Li

This study investigates the role of striatal cholinergic interneuron pathology and muscarinic signaling in dystonia using a mouse model, showing that ChI degeneration contributes to motor dysfunction but is not required for antimuscarinic drug effects.

The paper identifies a KRT17-positive, low-grade epithelial population in IPMNs with malignant features using spatial transcriptomics and single-cell RNA sequencing.

This study shows that increasing torsinB levels can reduce abnormal movements and neurodegeneration in DYT1 dystonia mouse models caused by torsinA loss-of-function.