William T. Dauer

This study investigates the role of striatal cholinergic interneuron pathology and muscarinic signaling in dystonia using a mouse model, showing that ChI degeneration contributes to motor dysfunction but is not required for antimuscarinic drug effects.

This study investigates how Parkinson's disease disrupts cholinergic interneuron control of GABAergic circuits in the striatum, showing reduced nicotinic AChR expression in interneurons in disease models.

This study identifies TRIM1 as an E3 ligase that ubiquitinates LRRK2, regulating its localization, degradation, and toxicity in Parkinson's Disease.

This study shows that the DYT-THAP1 mutation F81L impairs THAP1 transcriptional activity and disrupts CNS myelination by reducing YY1 DNA binding.

This study shows THAP1 regulates oligodendrocyte maturation by controlling lysosomal degradation of glycosaminoglycans in OPCs.

This study shows that increasing torsinB levels can reduce abnormal movements and neurodegeneration in DYT1 dystonia mouse models caused by torsinA loss-of-function.