Eileen S. Carpenter

Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer

The paper analyzes matched pre- and post-chemotherapy biospecimens in pancreatic cancer, revealing that cancer-associated fibroblasts undergo neural reprogramming, characterized by axonal guidance gene enrichment, which may contribute to chemoresistance and tumor progression.

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant features

The paper identifies a KRT17-positive, low-grade epithelial population in IPMNs with malignant features using spatial transcriptomics and single-cell RNA sequencing.