Author

Filippo Dragoni

Johns Hopkins UniversityORCID 0000-0002-8148-9914Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:CITE-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Francesco Roberto SimonettiiD· 4 shared Janet D'Angelo SilicianoiD· 4 shared Jun LaiiD· 4 shared Robert F. SilicianoiD· 4 shared Luis J. MontaneriD· 3 shared Milica MoskovljeviciD· 3 shared Angelica Camilo-ContrerasiD· 2 shared Anushka SinghaliD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Francesco Roberto SimonettiORCID

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4 papers

Recent·Most cited

Antigen Stimulation Reactivates HIV-1 Proviruses Despite Integration in Repressive Chromatin

Angelica Camilo-Contreras, Filippo Dragoni, Hao Zhang, Junlin Zhuo, Daniel F. Q. Smith, Arturo Casadevall, Jun Lai, Pablo Tebas, Janet D'Angelo Siliciano, Robert F. Siliciano, Stuart C. Ray, Luis J. Montaner, Joel N. Blankson, Francesco Roberto Simonetti

This study shows antigen stimulation can reactivate HIV-1 proviruses integrated in repressive chromatin, suggesting deeper latency may contribute to viral rebound.

bioRxiv · Jun 23, 2026 · PreprintImmunology

Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1

Vivek Hariharan, Jennifer A. White, Filippo Dragoni, Emily J. Fray, Nicholas M. Pathoulas, Milica Moskovljevic, Hao Zhang, Anushka Singhal, Jun Lai, Subul A. Beg, Eileen P. Scully, Elizabeth A. Gilliams, David S. Block, Jeanne C. Keruly, Richard D. Moore, , Robert F. Siliciano

The paper investigates superinfection with intact HIV-1 in people living with HIV-1, showing it leads to conditional replication of defective proviruses and nonsuppressible viremia.

Nature Microbiology · Oct 3, 2025Peer-reviewedMicrobiology

Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia

Fengting Wu, Milica Moskovljevic, Filippo Dragoni, Sahana Jayaraman, Nathan L. Board, Angelica Camilo-Contreras, Sílvia Bernal, Vivek Hariharan, Hao Zhang, Jun Lai, Anushka Singhal, Sébastien Poulin, Frédéric Chano, Annie Chamberland, Cecile L. Tremblay, , Francesco Roberto Simonetti

HIV-1 viremia not suppressed by effective ART can be caused by proviruses in CD4+ T cells reactive to autologous antigens.

Science Translational Medicine · Aug 13, 2025Peer-reviewedImmunology

Cognate Antigen Engagement Induces HIV-1 Expression In CD4+ T Cells From People On Long-Term ART

Milica Moskovljevic, Filippo Dragoni, Nathan L. Board, Fengting Wu, Jun Lai, Hao Zhang, James Robert White, Rebecca Hoh, Kenneth Lynn, Pablo Tebas, Karam Mounzer, Steven G. Deeks, Luis J. Montaner, Janet D'Angelo Siliciano, Robert F. Siliciano, Francesco Roberto Simonetti

The paper shows that cognate antigen engagement in CD4+ T cells on long-term ART increases HIV-1 transcription through T cell activation, suggesting a role in viral rebound.

Immunity · Nov 28, 2024Peer-reviewedImmunology