Oligomerization enables the selective targeting of intrinsically disordered regions by small molecules
Stasė Bielskutė, Borja Mateos, Muhammad Awawdy, Carla Garcia‐Cabau, Henri Niskanen, Carolina Sánchez, Lorenzo Bracaglia, Roberta Pierattelli, Isabella C. Felli, Marta Frigolé‐Vivas, Jesús Daza García, Antoni Riéra, Denes Hnisz, Xavier Salvatella
The paper shows a small molecule selectively targets an oligomeric form of a protein with an intrinsically disordered region, altering its interaction network and condensation properties.
Science Advances · Feb 27, 2026Peer-reviewedBiophysics