Antoni Riéra

Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo

This study shows that targeted KRAS(G12V) degradation causes durable lung adenocarcinoma regression in mice, with tumor relapse linked to proteolysis machinery dysregulation.

Oligomerization enables the selective targeting of intrinsically disordered regions by small molecules

The paper shows a small molecule selectively targets an oligomeric form of a protein with an intrinsically disordered region, altering its interaction network and condensation properties.

The PIN1-p38-CtIP signaling axis protects stalled replication forks from deleterious degradation

This study identifies the PIN1-p38-CtIP signaling pathway as essential for protecting stalled replication forks from degradation, independent of its role in homologous recombination.

HYL001, a new potent TGFβ signaling inhibitor that is efficacious against microsatellite stable CRC metastasis in combination with immune checkpoint therapy in mice

This paper describes the development of HYL001, a TGFβ inhibitor that effectively combats microsatellite stable CRC metastasis in mice when combined with immune checkpoint therapy.

Structure-based design of a Cortistatin analog with improved immunoregulatory activity against inflammatory bowel disease (IBD)

The paper designs a Cortistatin analog with improved immunoregulatory activity for treating inflammatory bowel disease by optimizing its structure and stability.