Carolina Sánchez

Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo

This study shows that targeted KRAS(G12V) degradation causes durable lung adenocarcinoma regression in mice, with tumor relapse linked to proteolysis machinery dysregulation.

Oligomerization enables the selective targeting of intrinsically disordered regions by small molecules

The paper shows a small molecule selectively targets an oligomeric form of a protein with an intrinsically disordered region, altering its interaction network and condensation properties.

HYL001, a new potent TGFβ signaling inhibitor that is efficacious against microsatellite stable CRC metastasis in combination with immune checkpoint therapy in mice

This paper describes the development of HYL001, a TGFβ inhibitor that effectively combats microsatellite stable CRC metastasis in mice when combined with immune checkpoint therapy.