Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7alpha,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant
Eylan Yutuc, Arunabha Ghosh, Jonas Abdel-Khalik, Anu Goenka, Mohsen Ali Asgari, Gloria Lopez-Castejon, Glenda M Beaman, Robert F Wynn, William G Newman, Simon A Jones, William J Griffiths, Yuqin Wang
This study shows that deleting CH25H and LIPA genes in humans eliminates 25-hydroxycholesterol but not 7alpha,25-dihydroxysterols, and increases cholesterol oxidation, which is partially reversed by hematopoietic stem cell transplant.
medRxiv · Jul 29, 2025 · PreprintGenetic & Genomic Medicine